Director, Human Resources Business Partner

Website Blueprint Medicines

How will your role help us transform hope into reality?

Are you passionate about making a difference in the lives of patients? Do you thrive in a fast-paced environment where your HR expertise can shape the success of cutting-edge therapies? We are seeking an experienced, driven HR Business Partner to join the Blue Crew and support our US Commercial and Legal & Compliance organizations in their mission to bring life-changing therapies to patients worldwide. This moment in time, as our teams are launching FDA approved AYVAKIT® (avapritinib), the first and only treatment for Indolent Systemic Mastocytosis, represents a once-in-a-lifetime opportunity to create immediate and longer-term impact for patients and the Company as a whole.

At Blueprint, we are driven by a deep commitment to innovating for patients and fostering an inclusive and empowering culture where each member of the Blue Crew can thrive. Our dedication to improving patients’ lives through transformative therapies is at the core of everything we do. As an HR Business Partner, you will play a pivotal role in shaping our people strategies and ensuring our talent across US Commercial and Legal & Compliance have what they need to operate at their best.

What will you do?

  • Strategic thought partnership with the business:
    • Collaborate with US Commercial and Legal & Compliance leadership to understand their strategic goals, challenges, and workforce requirements.
    • Create and implement talent development, engagement, and retention strategies designed to enable the business to meet its goals.
    • Identify and address talent and organizational-related opportunities and challenges, ensuring that our teams have the right talent and capabilities to achieve their objectives.
  • Shape overall HR and talent strategy:
    • Build strong, trusting relationships with SMEs across all HR disciplines
    • Support the evolution of our organizational talent strategy by offering perspective and ensuring the needs of the business are adequately reflected
    • Influence the evolution and utilization of data and people analytics, in partnership with HR SME’s, to inform business decisions, initiate action and liberate thinking.
  • Team effectiveness:
    • Seek to understand team dynamics and find creative and thoughtful ways to enhance team performance and ensure inclusive and empowering team environments
    • Design and facilitate workshops and focus groups to enhance team effectiveness, ensuring sessions are actionable and solutions are sustainable
    • Operate as a trusted sounding board, coach and mentor for team leaders and members
  • Performance management:
    • Execute core people processes in a way that is efficient, equitable and empowering for all involved
    • Support managers and employees in identifying, diagnosing, and addressing performance challenges
    • Encourage a performance-driven culture that recognizes and rewards exceptional contributions to our patient-centric mission.
  • Talent development and engagement:
    • In partnership with leaders and the Learning & Development function, design and deliver learning and development initiatives to enhance the capabilities of our US Commercial and Legal & Compliance teams, fostering a culture of continuous growth.
    • Implement employee engagement programs (including surveys) that strengthen collaboration, motivation, and a sense of purpose among team members.
    • Advance our Equity, Diversity & Inclusion (ED&I) efforts company-wide through self-education, active engagement in initiatives, and pull-through of ED&I concepts into our people processes and all other aspects of how we engage with our talent at Blueprint.
  • Employee relations:
    • Act as a trusted advisor to employees and managers, offering support and guidance on HR-related matters and creating a safe space for employees to come for support and guidance
    • Foster an inclusive, equitable and diverse work environment
    • Mediate and resolve complex employee relations issues; conduct thorough and objective investigations when necessary.
    • Ensure compliance with all relevant employment laws and regulations
  • Organizational design & change management:
    • Collaborate with leadership to design effective organizational structures and manage change initiatives smoothly.
    • Develop and implement strategies for organizational effectiveness and efficiency.

What minimum qualifications do we require? 

  • Bachelor’s Degree
  • Minimum of 8 years’ progressive human resources experience as an HR Business Partner
  • Ability to travel for in-person regional and national meetings throughout the year

What additional qualifications will make you a stronger candidate? 

  • Experience in biotechnology, pharmaceutical or medical device or technology industry preferred.
  • Strong business acumen and proven ability to diagnose and co-develop solutions with and for the business
  • High integrity and professionalism with ability to remain calm and optimistic in challenging situations
  • Strong and reliable execution and follow-through coupled with an ability to think strategically, operate in ambiguity, and remain flexible and adaptable in a fast-paced environment
  • Humble, and believes their talents can be developed (through hard work, deliberate development strategies, and feedback from others); a growth mindset.
  • Authentic, active communicator with the proven ability to form relationships and establish rapport, creating a culture of trust and empowerment at all levels.
  • Commitment to upholding our Core Values of Patients First, Thoughtfulness, Urgency, Trust, Optimism

Why Blueprint?

At Blueprint Medicines, we achieve impactful results because of our global crew of compassionate innovators – the Blue Crew. Through authentic relationships and our collective entrepreneurial spirit and action, we are each empowered to take ownership and execute with strategic prioritization. We put trust in our people to break through norms and conventions using their individual strengths and insights, which drives our success.

This is the place where the extraordinary becomes reality, and you could be part of it. Patients are waiting. Are you ready to make the leap?

COVID-19 Vaccination Requirement

As a biotechnology organization, it is our responsibility to do everything we can to safeguard the health and safety of our workforce, our communities, and the patients we serve.  That is why, prior to their start date, new hires must provide confirmation that they are fully vaccinated against COVID-19, or receive approval by Blueprint for an exemption for health reasons contraindicating the vaccines or sincerely held religious beliefs.  Accommodation requests for either of these reasons should be made to

Equity, Diversity, Inclusion and Affirmative Action

At Blueprint Medicines, we foster a culture of equity, diversity and inclusion.  A proud Equal Employment Opportunity and Affirmative Action employer, we consider all qualified applicants without regard to race, color, sex, gender identity or expression, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable law.  We are also an E-Verify Employer.  We will make reasonable accommodations, absent undue hardship, for qualified individuals with known disabilities. If you are an individual with a disability in need of an accommodation with the application or recruiting process, please reach out to

For more information, please see our EEO-AA Policy Statement, the EEO Know Your Rights Poster, as well as our Pay Transparency Statement.

Who We Are:

Blueprint Medicines is a global precision therapy company that invents life-changing therapies for people with cancer and blood disorders. Applying an approach that is both precise and agile, we create medicines that selectively target genetic drivers, with the goal of staying one step ahead across stages of disease. Since 2011, we have leveraged our research platform, including expertise in molecular targeting and world-class drug design capabilities, to rapidly and reproducibly translate science into a broad pipeline of precision therapies. Today, we are delivering approved medicines directly to patients in the United States and Europe, and we are globally advancing multiple programs for systemic mastocytosis, lung cancer and other genomically defined cancers, and cancer immunotherapy. For more information, visit and follow us on Twitter (@BlueprintMeds) and LinkedIn.

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